| Autor: |
Abdelaal, Essam Bakr, Abdelsamie, Heba Mahmoud, Attia, Shady Mahmoud, Amr, Khalda Sayed, Eldahshan, Ramadan M., Elsaie, Mohamed L. |
| Předmět: |
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| Zdroj: |
Journal of Cosmetic Dermatology; Nov2021, Vol. 20 Issue 11, p3679-3683, 5p |
| Abstrakt: |
Background: Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is believed to play an important role in the development of acne vulgaris. Aim of the Work: To investigate the presence of GM‐CSF 3928C/T and GM‐CSF 3606 T/C promoter gene polymorphisms in Egyptian acne patients. Methods: To examine whether GM‐CSF single nucleotide polymorphisms (SNPs) are associated with susceptibility to acne vulgaris (AV), we investigated the genotype and allele frequencies of the SNP 3928C/T and 3606T⁄C of the GM‐CSF gene in 100 Egyptian acne patients (29 with mild acne, 38 with moderate acne, and 33 with severe acne) and 100 controls, using a PCR restriction fragment length polymorphism (RFLP) method. Results: There was a highly significant difference in genotype and allele frequencies of the 3928C/T group between patients with acne vulgaris and controls for the SNP site. Regarding the 3606 T/C subgroup only a marginal significant difference was found between cases and controls in TC pattern (p = 0.039); with the TC genotype appearing more in cases (53% of patients) than controls (35% of healthy controls). Conclusion: We report a novel GM‐CSF 3928C/T promoter gene polymorphism contributing to the pathogenesis of acne in Egyptian population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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