| Abstrakt: |
Background: Chronic urticaria (CU) is a complex disease associated with a systemic inflammatory response. This inflammation could be related to the release of adipokines with proinflammatory properties such as leptin. In recent years, leptin has been associated with different diseases, wound healing and immune cell activation. Objective: to evaluate leptin levels in patients with chronic spontaneous urticaria, to investigate the possible role of leptin in chronic spontaneous urticaria pathogenesis and to outline relationships between serum leptin and urticaria severity. Methods: A case-control study was conducted at the allergy and immunology outpatient clinic at Ain Shams University hospital, and included 60 patients with chronic spontaneous urticaria and 30 healthy individuals who were group matched with cases for age and sex serving as the control group. All the patients were subjected to the following: Full history, clinical examination, calculation of body mass index (BMI), CBC, ESR, CRP, Thyroid profile, AST, ALT, Skin prick test or Specific IgE for common allergens, and measurement of serum leptin level after overnight fasting by ELISA. Results: The present study showed that patients with chronic spontaneous urticaria had higher level of serum leptin in comparison to control subjects and there was a positive correlation between leptin level and urticaria severity which was assessed by urticaria activity score. Conclusion: serum leptin is increased in chronic spontaneous urticaria and it is positively correlated to urticaria severity. [ABSTRACT FROM AUTHOR] |
