| Autor: |
Elshakaa, Nagwa, Bahaa, Nevine, Zeid, Asmaa Abo, Latif, Heba Abdel |
| Předmět: |
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| Zdroj: |
QJM: An International Journal of Medicine; 2021 Supplement, Vol. 114, pi153-i153, 1/4p |
| Abstrakt: |
Background: Nanoparticles (NPs) have unique and novel properties that lead to a diverse array of products with applications in diagnosis, drug delivery, food industry, paints, electronics, environmental cleanup, cosmetics and sunscreens. Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used engineered nanoparticles in consumer products. They are utilized in many commercial products including cosmetics, paints, textiles, and personal hygiene products. The study aimed to assess the effects of zinc oxide nanoparticles administered Intranasal or intravenous on lung tissue. Materials & methods: twenty-five male Wistar rats were divided into Group I; control group, group II (Intranasal administered group) group II (Intravenous administered group). The animals were injected with 4 mg/kg of ZnO NPs. Rat Lungs were processed for histological, immunohistochemical. Results: ZnO NPs caused thickening of interalveolar septa. Mononuclear cells were seen infiltrating the interalveolar septa. Many dilated blood vessels exhibited focal disruption and focal thickening of their wall. Tumor necrosis factor-alpha (TNF-a) immune reactivity was significantly increased. These findings increased mainly in the intranasal administered group when compared with the intravenous group. Conclusion: ZnO NPs administration caused toxic effects on the histological structure of albino rat lung. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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