| Autor: |
Truong, Luu Hong, Cuong, Nguyen Hieu, Dang, Tran Huu, Dung, Trinh Thi My, Cham, Pham Thi, Hanh, Tran Thi Hong, Quang, Tran Hong, Dang, Nguyen Hai, Cuong, Nguyen Xuan, Nam, Nguyen Hoai, Minh, Chau Van |
| Předmět: |
|
| Zdroj: |
Natural Product Research; Oct 2021, Vol. 35 Issue 20, p3390-3395, 6p |
| Abstrakt: |
In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of Helicteres viscida was found to exhibit inhibitory effect on LPS-induced NO production in RAW264.7 cells. Phytochemical investigation of this plant led to isolation of four sulphated flavones (1–4), including one new compound 5,3′,4′-trihydroxy-7-methoxy-8-O-sulphate flavone (1), and two pregnane-type steroids (5 and 6), including one new compound 7-epi-heligenin B (5). Their structures were elucidated by 1D and 2D NMR as well as HR-QTOF-MS experiments. Among isolated compounds, heligenin B (6) exhibited potent inhibitory effect on LPS-induced NO production in RAW264.7 cells with IC50 of 1.23 ± 0.05 µM. The activity of 6 was comparable to that of the positive control cardamonin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
