| Autor: |
Fang-Lin Lu, Zhao An, Ye Ma, Zhi-Gang Song, Cheng-Liang Cai, Bai-Ling Li, Guang-Wei Zhou, Lin Han, Jun Wang, Yi-Fan Bai, Xiao-Hong Liu, Jia-Feng Wang, Xu Meng, Hai-Bo Zhang, Jian Yang, Nian-Guo Dong, Sheng-Shou Hu, Xiang-Bin Pan, Cheung, Anson, Fan Qiao |
| Předmět: |
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| Zdroj: |
Heart; Oct2021, Vol. 107 Issue 20, p1664-1670, 7p |
| Abstrakt: |
Objective: Tricuspid regurgitation (TR) is a common valvular heart disease with unsatisfactory medical therapeutics and high surgical mortality. The present study aims to evaluate the safety and effectiveness of transcatheter tricuspid valve replacement (TTVR) in high-risk patients with severe TR.Methods: This was a compassionate multicentre study. Between September 2018 and November 2019, 46 patients with TR who were not suitable for surgery received compassionate TTVR under general anaesthesia and the guidance of trans-oesophageal echocardiography and fluoroscopy in four institutions. Access to the tricuspid valve was obtained via a minimally invasive thoracotomy and transatrial approach. Patients' data at baseline, before discharge, 30 days and 6 months after the procedure were collected.Results: All patients had severe TR with vena contracta width of 12.6 (11.0, 14.5) mm. Procedural success (97.8%) was achieved in all but one case with right ventricle perforation. The procedural time was 150.0 (118.8, 180.0) min. Intensive care unit time was 2.0 (1.0, 4.0) days. 6-month mortality was 17.4%. Device migration occurred in one patient (2.4%) during follow-up. Transthoracic echocardiography at 6 months after operation showed TR was significantly reduced (none/trivial in 33, mild in 4 and moderate in 1) and the primary safety end point was achieved in 38 cases (82.6%). Patients suffered from peripheral oedema and ascites decreased from 100.0% and 47.8% at baseline to 2.6% and 0.0% at 6 months.Conclusions: The present study showed TTVR was feasible, safe and with low complication rates in patients with severe TR. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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