| Autor: |
Seğmenoğlu, Mansur Seymen, Akıllı, Harun |
| Předmět: |
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| Zdroj: |
Veterinary Journal of Mehmet Akif Ersoy University; 2021, Vol. 6 Issue 2, p68-71, 4p |
| Abstrakt: |
St. John's wort oil is a herbal product that has therapeutic features. Our aim in this study is to investigate the effects of St. John's wort oil on irritated gastrointestinal mucosa and liver. The study is based on experimental animal trials. 21 healthy swiss albino mice were randomly divided into three groups: control group, group-2, group-3. The single dose of methotrexate (20 mg/kg) was given intraperitoneally on the 1st day to the group-2 and group-3. St. John's wort oil (4 ml/kg) was given by gavages into the stomach daily for 7 days to the group-3. Following the necropsy, the gastrointestinal mucosa samples and the liver tissue samples were collected for histopathological evaluation. No pathological changes were found in the gastrointestinal mucosa and liver of control group. No pathological changes were found in the mice of group-3 in histopathological examination of the gastric mucosa. Significant hyperplasia and mononuclear cell infiltrations in lamina propria were observed in the mice of the group-2's intestinal mucosa. The group-3 mice's intestinal mucosa was similar to control group's intestinal mucosa. In liver histopathology, mononuclear cell infiltrates with locally degenerative changes in the periportal area, thrombotic changes in the vessels, bile duct hyperplasia, megalocytosis in hepatocytes in some areas, vascular congestion and sinusoidal enlargement were observed in the livers of group-2 mice. Only a mild sinusoidal enlargement was noted in group-3's liver. According to the data we obtained in our study, St. John's wort oil has protective and restorative effects especially on liver and intestinal mucosa. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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