Isolation and structure determination of new chymotrypsin inhibitory peptides streptopeptolins B and C.

Autor: Tiwari, Ankit, Kaweewan, Issara, Miyake, Yuto, Hemmi, Hikaru, Kodani, Shinya
Předmět:
Zdroj: Natural Product Research; Aug2021, Vol. 35 Issue 16, p2700-2706, 7p
Abstrakt: New chymotrypsin inhibitory peptides named streptopeptolins B and C were isolated from Streptomyces olivochromogenes. Structures of streptopeptolins B and C were determined to be cyclic depsipeptides possessing 3-amino-6-hydroxy-2-piperidone unit by interpretation of NMR spectra and ESI-MS. Streptopeptolins B and C showed inhibitory activities to chymotrypsin with IC50 of 8.0 and 12.0 μg/mL, respectively. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index