| Abstrakt: |
Orofacial diseases of multidiscipline nature from carious lesions to tumors are significant diseases attack a large number of individuals around the world. However, In the recent years, bioinformatics methods have been reported to analyses several loci of simultaneously. Moreover, Analysis of molecular variance (AMOVA) (23) was performed to measure the ge netic distance between the Iraqi popu lation sample and reference data from populations. In this study, we analyzed the genetic polymorphisms of 23 Y-STR loci from PowerPlex® Y23 system in 313 unrelated healthy male individuals from Iraqi populations, and observed 283 different haplotypes including 269 unique haplotypes and 16 duplicate haplotypes. in which 283 different haplotypes was identified classified into 264 (93, 23%) as a unique Haplotype and 19 (6, 77%) as replicated haplotype among individuals. The highest haplotype were found in sample H45, H85, H135,H213 and H241 at frequency 0.010 ( haplotype replicated 3 times ), While 264 haplotype with 0.0033 frequency and haplotype diversity was 0.996 with a discrimination capacity 0.93 respectively. The gene diversity values ranged from 0.3942 at DYS438 to 0.9607 at DYS385a/b. Such results indicated that the 23 Y-STR loci were highly polymorphic in Bagdad population and played crucial roles in forensic application as well as population genetics. For the first time, we reported the genetic diversity of male lineages in Bagdad population at a high-resolution level of 23 Y-STR set and consequently contributed to familial searching, Odontologic science application tracking, and anthropology analysis of Bagdad population. Orofacial diseases of multidiscipline nature from carious lesions to tumors are significant diseases attack a large number of individuals around the world. However, In the recent years, bioinformatics methods have been reported to analyses several loci of simultaneously. Moreover, Analysis of molecular variance (AMOVA) (23) was performed to measure the ge netic distance between the Iraqi popu lation sample and reference data from populations. In this study, we analyzed the genetic polymorphisms of 23 Y-STR loci from PowerPlex® Y23 system in 313 unrelated healthy male individuals from Iraqi populations, and observed 283 different haplotypes including 269 unique haplotypes and 16 duplicate haplotypes. in which 283 different haplotypes was identified classified into 264 (93, 23%) as a unique Haplotype and 19 (6, 77%) as replicated haplotype among individuals. The highest haplotype were found in sample H45, H85, H135,H213 and H241 at frequency 0.010 ( haplotype replicated 3 times ), While 264 haplotype with 0.0033 frequency and haplotype diversity was 0.996 with a discrimination capacity 0.93 respectively. The gene diversity values ranged from 0.3942 at DYS438 to 0.9607 at DYS385a/b. Such results indicated that the 23 Y-STR loci were highly polymorphic in Bagdad population and played crucial roles in forensic application as well as population genetics. For the first time, we reported the genetic diversity of male lineages in Bagdad population at a high-resolution level of 23 Y-STR set and consequently contributed to familial searching, Odontologic science application tracking, and anthropology analysis of Bagdad population. [ABSTRACT FROM AUTHOR] |
