| Abstrakt: |
In recent years, diabetes is one of the diseases that cause the most death and disability. It is a global public health problem. Diabetes is mainly due to metabolic disorders caused by insufficient insulin or high blood sugar in the body. Concentration range (4.4–6.6 mM). Therefore, the development of fast and reliable blood glucose sensors has been receiving widespread attention in the diagnosis of diabetes. This article is based on the nano-conjugate electrochemical aptamer sensor, and its performance is studied by detecting dopamine, using the affinity of the nucleic acid aptamer and the target to be stronger than the principle of base force between the nucleic acid aptamer and the complementary strand, and Combined with blood glucose meter to detect dopamine. The results showed that the incubation time of dopamine and the catalytic time of invertase were 30 min and 120 min respectively; the linear detection range of dopamine was 0.45–10 mmol/L, the correlation coefficient was 0.997, and the detection limit was 0.45 mmol/L; The chemical aptamer sensor can maintain the bioelectrocatalytic activity of glucose oxidation, and the electrode detection of glucose shows good electrochemical performance, with high sensitivity, good stability, strong anti-interference ability and other advantages, which can meet the requirements of noninvasive blood glucose detection. Need, has great application prospects in the noninvasive detection of blood glucose. [ABSTRACT FROM AUTHOR] |
