Adaptation to Intermittent Hypoxia: Influence on the State of Endothelial Function.

Autor: Katuntsev, V. P., Baranov, M. V., Zakharov, S. Yu., Suchostavtseva, T. V., Puchkova, A. A., Stavrovskaya, D. M.
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Zdroj: Human Physiology; May2021, Vol. 47 Issue 3, p306-312, 7p
Abstrakt: This study involving ten apparently healthy male volunteers aged 19 to 31 years was aimed at establishing possible effects of a three-week course of normobaric intermittent hypoxic trainings (IHTs) on the state of endothelial function (EF). IHTs were performed on a daily basis with each training session lasting 60 min and the FIO2 operating level equal to 9% in the 5-min hypoxia/5-min normoxia cyclic mode. The EF state and the pulse wave velocity (PWV, ΔPWV) were evaluated using a Tonocard device by a noninvasive method based on the capacity of the endothelium to release nitric oxide (NO) during reactive hyperemia. The adaptation to intermittent hypoxia was accompanied by a significant (p < 0.05) 34.3% increase in the erythropoietin (Epo) concentration, a larger than twofold increase in the reticulocyte count, a 6.4% increase in the erythrocyte count, and a 4.1% increase in the hemoglobin content. After the course of IHTs, the value of EF used to increase significantly by 38.9% (p < 0.05), which could be caused by a higher level of endothelium-dependent relaxation in muscular arteries. At the same time, the PWV and ΔPWV values reflecting the elastic–viscous characteristics of vascular wall remained at the prior-to-the study level. The data obtained in the study are discussed in this article from the position of possible trigger effects of the hypoxia-inducible transcription factors (HIF-1 and HIF-2), which create a broad molecular basis for the activation of endothelial cells and the increase in the NO production. Apart from increasing the erythrocyte production, which is greatly important for maintaining oxygen homeostasis under reduced PO2, Epo can participate in the complicated mechanisms of ventilatory response, activation of NO production by endothelial cells, and angiogenesis during the adaptation of the body to hypoxia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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