| Autor: |
Alalsaidissa, Nouri Jaffar, Abdullah, Zahraa Ali, Abed-AlkadumAlajeely, Ausama, Mohammed Ali, Saad Hasan, Mohammed Al-Alwany, Shakir H |
| Předmět: |
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| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Apr-Jun2021, Vol. 15 Issue 2, p1305-1311, 7p |
| Abstrakt: |
This retrospective case-control study to assess the impact of Cyclin D1 and CDK4 expression along with EBV infection with Hodgkin’s lymphoma (HL).80 lymph node included in this study; (40) formalin-fixed, paraffin- embedded biopsies from Hodgkin’s lymphoma (HL), and (40) apparently healthy lymph nodes as control group. EBV detection was done by CISH whereas IHC detection system was used to evaluate both Cyclin D1 & CDK4 gene expression. The positive –EBERs CISH reactions detected in 16 / 40 (40 %) of Hodgkin lymphoma tissues while positive - EBERs reactions detected in 3 out of 40 tissues (7.5%) in control lymph nodes tissues. Statistically was found highly significant between study groups (P value = < 0.05). Cyclin D1 & CDK4 -IHC were detected in 40% and 52.5% of HL, respectively. Statistically, significant differences noticed among negative, low and moderate scoring of tissues (P<0.05). Significant EBV gene expressions along with higher percentage of tissues in which Cyclin D1 & CDK4 genes being expressed may be indicator their possible role in the pathogenesis and / or the carcinogenesis of a subset of our Hodgkin’s lymphoma cases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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