| Autor: |
Ha, Zhuo, Yu, Chengdong, Xie, Changzhan, Wang, Guanyu, Zhang, Ying, Hao, Pengfei, Li, Jinfeng, Li, Zhuoxin, Li, Yanwei, Rong, Fulong, Nan, Fulong, Zhang, He, Zhuang, Xinyu, Xie, Yubiao, Shi, Ning, Lu, Huijun, Jin, Ningyi |
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| Zdroj: |
Archives of Virology; Jul2021, Vol. 166 Issue 7, p1951-1959, 9p |
| Abstrakt: |
A novel circovirus designated "porcine circovirus type 4" (PCV4) was recently reported in pigs with severe clinical disease in Hunan Province, China. Relatively little is known about the molecular epidemiology of this recently discovered virus. In order to assess the prevalence of PCV4 infection in pigs and to analyze its genomic characteristics, 1683 clinical samples were collected in Inner Mongolia, China, from 2016 to 2018. The overall infection rate of PCV4 was 1.6% (27/1683) at the sample level and 21.6% (11/51) at the farm level, with rates ranging from 3.2% (1/31) to 20.0% (6/30) on different PCV4-positive pig farms. In addition, the PCV4 infection rates at both the sample and farm level increased from 2016 to 2018. This also showed that PCV4 was present in pigs in 2016 in China and therefore did not arrive later than this date. Additionally, our findings showed that PCV4 infections had no association with PCV2 or PCV3 infections. We sequenced the complete genomes of three PCV4 strains and found that the PCV4 strains had a high degree of genetic stability but shared less than 80% sequence identity with other circoviruses. We identified six amino acid mutations in the Rep protein and seven in the Cap protein. Phylogenetic analysis based on Cap and Rep sequences confirmed that the PCV4 strains grouped in an independent branch. Our findings provide important information about the prevalence and genetic characteristics of PCV4 strains. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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