| Autor: |
Geier, Johannes, Schubert, Steffen, Schnuch, Axel, Szliska, Christiane, Weisshaar, Elke, Kränke, Birger, Werfel, Thomas, Ruëff, Franziska, Schröder‐Kraft, Claudia, Buhl, Timo, Baron, Jens Malte, Grabbe, Jürgen, Siedlecki, Katharina, Strom, Kerstin, Hofmeier, Kathrin Scherer, Worm, Margitta, Simon, Dagmar, Effendy, Isaak, Dickel, Heinrich, Fartasch, Manigé |
| Předmět: |
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| Zdroj: |
Contact Dermatitis (01051873); Jun2021, Vol. 84 Issue 6, p407-418, 12p |
| Abstrakt: |
Background: In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false‐positive, or the breakdown test is false‐negative. Objectives: To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents. Patients and Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790). Results: Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non‐fragrance baseline series allergens), Group II rather resembled Group I. Conclusions: Not every positive reaction to FM I in patients with negative breakdown tests is false‐positive. There may be false‐negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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