| Autor: |
Mohsin, Ibtihal Hameed, Daim Saleh, Mohammed Abdul, Hassan, Ibtesam Badday, Challob, Mohamed Sabaa |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Apr2021, Vol. 21 Issue 1, p1883-1888, 6p |
| Abstrakt: |
The human cytomegalovirus (HCMV) is an important human pathogen primarily affecting immunocompromised patients, like Renal failure patients, transplant recipients or HIV-infected individuals. Renal failure disease is a wide dissemination among kidney patients in Ba’quba City. The aim of the study was carried out to Molecular detection of CMV among20 renal failure patients and detection of several single nucleotide polymorphisms (SNP) in HLA-DRB1 among 20 patient suffering from acute or chronic renal failure whom admitted to Ibn Sina Center for kidney Dialysis in Baquba Teaching Hospital. This study was conducted for the period from 1/12/2019 to 15/6/2020 in Baquba city in Iraq,with age ranged between (13-76) years. The samples were diagnosed by molecular and genetics tests. Detection of human cytomegalovirus DNA in serum between patients with renal failure and control by using sensitive molecular techniques, the obtained results showed that the HCMV DNA was detected in (6 out of 45) or 6 % in patients, while in control group (0 out of 5) or 0.0%. Also, the HCMV DNA was detected in males 1(16.66) %. while in females was 5(83.34) %, while in control group (0 out of 5) or 0.0% with highly percent differences was noticing among both sexes. These results showed the age group 60-70 showed the highest rate of infection among other groups. The alignment results of the 237 bp samples revealed the presence of tow genetic variations variably distributed in some of the analyzed samples in comparison with the referring HLA-DRB1 genetic sequence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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