| Abstrakt: |
Autophagy and inflammasome are crucial for controlling Toxoplasma gondii infection. T. gondii infection during pregnancy can cause damage to the fetus, birth defects, reduced birth weight, and congenital disorders. The aim of the study is to investigate the expression of LC3C, NLRP3 and MYD88 in placental tissue with all study groups. One hundred ninety-one women participated in this study: 92 with spontaneous abortion positive for toxoplasmosis, 84 with spontaneous abortion negative for toxoplasmosis and 15 women undergoing elective termination (induced abortion). Immunohistochemistry streptavidin-peroxidase (SP) assay was used to detect the protein expression of LC3C, NLRP3 and MYD88 in the trophoblastic tissue. Our result of the positive group showed that LC3C and NLRP3 were mainly expressed in the nucleus and cytoplasm of trophoblastic cells and an inflammatory cell, while MYD88 was expressed in the cytoplasm of trophoblastic cells and an inflammatory cell. The expression of LC3C, NLRP3 and MYD88 in the positive group was significantly higher than that in the negative group and induced abortion (p<0.001), these results suggest the increased expression of LC3C, NLRP3 and MYD88 in placental tissues may be associated with spontaneous abortion in infected women. In conclusion, these results suggest the increased expression of LC3C, NLRP3, and MYD88 in placental tissues may be associated with spontaneous abortion in infected women. [ABSTRACT FROM AUTHOR] |
