Limited impact of Der p 23 IgE on treatment outcomes in tablet allergy immunotherapy phase III study.

Autor: Stranzl, Thomas, Ipsen, Henrik, Christensen, Lars Harder, Eiwegger, Thomas, Johansen, Niels, Lund, Kaare, Andersen, Peter Sejer
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Zdroj: Allergy; Apr2021, Vol. 76 Issue 4, p1235-1238, 4p
Abstrakt: Keywords: cinical effect; Der p 23; diagnosis; HDM SLIT-tablets EN cinical effect Der p 23 diagnosis HDM SLIT-tablets 1235 1238 4 04/14/21 20210401 NES 210401 Allergen 23 from I Dermatophagoides pteronyssinus i (Der p 23) has recently been identified as a novel major house dust mite (HDM) allergen based on the high prevalence of Der p 23-specific IgE in HDM-sensitized individuals.1 The clinical importance of Der p 23 sensitization is unknown. +:allergen-specific IgE > 0.7kUA/L; -:allergen-specific IgE < 0.7kUA/L. a:Der p 1 and/or Der p 2 IgE; b:Der p 1 and/or Der p 2 and/or Der p 23 IgE. A similar observation was made in a different population.3 GLO:1X5/01apr21:all14200-fig-0001.jpg PHOTO (COLOR): 1 A, IgE sensitization frequencies: Der p 1, Der p 2, Der p 10 and Der p 23 (blue), combined Der p 1 and Der p 2 sensitization with and without Der p 10 and Der p 23 (orange, red). The mean level of Der p 23 IgE in the MITRA population is 2.5- to 3.5-fold lower compared with Der p 1 and 2, and even below the level of IgE specific for the minor allergen Der p 10 (Figure 1B). [Extracted from the article]
Databáze: Complementary Index