| Autor: |
Yusuf, D., Lusiyanti, Y., Tetriana, D., Rahardjo, T., Purnami, S., Lubis, Lukmanda Evan, Nuzulia, Nur Aisyah, Hidayati, Nur Rahmah |
| Předmět: |
|
| Zdroj: |
AIP Conference Proceedings; 2020, Vol. 2346 Issue 1, p1-6, 6p |
| Abstrakt: |
The two different biomarkers were used in this study, comets to see the effects of exposure and chromosomal aberration to evaluate initial and residual lesions (not repaired or wrongly repaired) on lymphocytes of medical radiation workers. The purpose of this study is to provide preliminary data on the genotoxic implications resulting from chronic low-dose ionizing radiation exposure. A Primary DNA damage assessment was carried out using a comet alkaline test. The data obtained is then compared with the results of the chromosome aberration (CA) test. Genetic damage evaluation was carried out on 54 subjects (30 exposed and 24 controls). The results obtained in primary DNA damage, which was exposed indicating there was a significant increase in the comet length value of the p group <0.05,but the TM value was lower than in the control group although it was not significant. There was an increase in the frequency of CAs in workers compared to controls. The dicentric chromosome value of the exposed group was obtained 0.13 per 250 cells and fragment also 0.13 per 250 cells while in control the value of dicentrics and fragment had no found at all. But the value was still within normal limits where the range of background values is 1-3. The conclusions from this study indicate the possible genotoxic implications of nuclear medicine in employees exposed to low-dose ionizing radiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
