| Abstrakt: |
Background: This research aimed to examine the secondary metabolites in the ethanol extract of Parkia speciisa Hassk peels and determine the effect of the P speciisa Hassk peels on the reduction in total cholesterol levels of male hypercholesterolemia white rats. Methods: Thirty white male rats were divided into six treatment groups (n=5): Group I: normal control (0.5% CMC Na suspension), Group II: negative control (high cholesterol feed), Group III: positive control (suspension simvastatin), Group IV, V, VI: hypercholesterolemia rat received P speciisa Hassk shell at dose of 300, 400, and 500 mg/kg BW orally for 14 days. The total cholesterol levels were measured on days 0, 14, 28, 35. Results: Quantitative test showed that the ethanol extract of P speciisa peels contained 0.21% alkaloids (w/w), 8.34% flavonoids (w/w), 4.21% tannins (w/w) and 0.18% saponins (w/w). The ethanol extract of P. speciisa peels at a dose of 300 mg/kg BW was able to reduce total cholesterol levels in hypercholesterolemia white mice (52 mg/dL). Conclusion: The ethanol extract of P speciisa peels can be considered as an effective treatment for hyperlipidemia disease. [ABSTRACT FROM AUTHOR] |
