| Abstrakt: |
The current study was to investigate the effect sesame oil (Sesamum indicum L) on glycosylated hemoglobin, blood glucose, Malondialdehyde, semen and hormonal parameters, in addition the histopathological changes on pancreas in diabetic pigs. The physiological indices were examined in control, diabetic and oil treated diabetic pigs. Eighteen male pigs were randomly assigned into three groups, group one as control, group two diabetic as positive control and group three diabetic treatment with sesame oil at dose (1ml/kg) orally, after 30 days whole blood samples were collected to measure the hemoglobin A1c and other samples were separated into serum for blood glucose and MDA and hormonal assays. Epididymal taken for sperm parameters examined, all animals were sacrificed and pancreas was taken for histological study. Outcomes of this study indicate that significantly reduction in serum Malondialdehyde level in associated with lowered levels of blood glucose and hemoglobin A1c, While, significantly elevation in serum testosterone, FSH and LH levels accompanied with the improved spermatogenesis were observed in group treated with the sesame oil. In addition, the a significant islet langer hans restoration was notable. Conclusion: The oil has antioxidant and ameliorated effects on pancreatic function and markedly improved sperm profile. [ABSTRACT FROM AUTHOR] |
