Effects of Zoniporide and BMA-1321 Compound on the Rate of Oxygen Absorption by Cardiomyocyte Mitochondria in Rats with Experimental Chronic Heart Failure.

Autor: Spasov, A. A., Gurova, N. A., Popova, T. A., Perfilova, V. N., Vishnevskaya, V. V., Kustova, M. V., Ovsyankina, N. V., Ozerov, A. A.
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Zdroj: Bulletin of Experimental Biology & Medicine; Jan2021, Vol. 170 Issue 3, p316-320, 5p
Abstrakt: Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure. The effect of BMA-1321 was more manifest (53%; p<0.05) in comparison with zoniporide (35%; p<0.05). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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