Consolidative or palliative whole brain radiation for secondary CNS diffuse large B-Cell lymphoma.

Autor: Walburn, Tyler, Grover, Natalie S., Shen, Colette J., Ranganathan, Raghuveer, Dittus, Christopher, Beaven, Anne W., Wang, Andrew Z., Wang, Kyle
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Zdroj: Leukemia & Lymphoma; Jan2021, Vol. 62 Issue 1, p68-75, 8p
Abstrakt: We analyzed 25 patients receiving whole brain radiation (WBRT) for secondary CNS lymphoma (SCNSL), grouped by consolidative intent (after complete/partial response, n = 13) vs. palliative intent (initial CNS treatment, primary refractory disease, or CNS progression, n = 12). Median WBRT dose for the consolidative and palliative cohorts were 24 Gy and 30 Gy, respectively. For 13 patients receiving consolidative WBRT, median OS was 24 months from WBRT and 2-year OS was 64%. Three patients had CNS relapse at 2, 9, and 24 months after consolidative WBRT. For 12 patients receiving palliative WBRT, median OS was 3 months from WBRT and two-year OS was 8%. All 10 patients with neurologic symptoms had documented improvement. In conclusion, consolidative WBRT after chemotherapy response led to reasonable long-term survival and may be an effective strategy for SCNSL, especially transplant-ineligible patients and/or isolated CNS recurrence. Palliative WBRT effectively improved neurologic symptoms, but survival was usually only months. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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