| Autor: |
Teixeira Mendes, Elisa, Garcia Paez, Jorge Isaac, Rosa Ferraz, Juliana, Marchi, Ana Paula, França e Silva, Ivan Leonardo Avelino, Vieira Batista, Marjorie, Munhoz de Lima, Ana Lucia, Rossi, Flávia, Levin, Anna Sara, Figueiredo Costa, Silvia |
| Zdroj: |
Revista do Instituto de Medicina Tropical de São Paulo; 2020, Vol. 62, p1-7, 7p, 3 Diagrams, 4 Charts, 1 Graph |
| Abstrakt: |
Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen in the last decade. Increased resistance to sulfamethoxazole/trimethoprim (SMX/TMP) has been reported in S. maltophilia strains in the past few years, leading to few therapeutic options. We conducted a prospective multicenter study at two Brazilian teaching hospitals that identified S. maltophilia isolates and evaluated their antimicrobial susceptibility profile, SMX/TMP resistance genes and their clonality profile. A total of 106 non-repeated clinical samples of S. maltophilia were evaluated. Resistance to SMX/TMP was identified in 21.6% of the samples, and previous use of SMX/TMP occurred in 19 (82.6%). PCR detected the sul1 gene in 14 of 106 strains (13.2%). Of these isolates, nine displayed resistance to SMX/TMP. The resistant strains presented a polyclonal profile. This opportunistic pathogen has emerged in immunocompromised hosts, with few therapeutic options, which is aggravated by the description of emerging resistance mechanisms, although with a polyclonal distribution profile. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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