| Autor: |
Conde Maria, Bernardo, Catarina Quadros, Ana, Alves, Natália, Coutinho, João |
| Zdroj: |
BMJ Case Reports; 12/21/2020, Vol. 13, p1-6, 6p |
| Abstrakt: |
Type 1 multiple endocrine neoplasia (MEN-1) syndrome is an autosomal dominant disease, associated with germline mutations in the MEN-1 tumour suppressor gene (encoding the menin protein). Recent studies, through a better characterisation of the functions of the menin protein, have started to demonstrate how changes in this protein may be related to breast cancer. We present the case of a patient whose diagnosis of MEN-1 syndrome was made during treatment for a breast tumour—this diagnosis was obtained after finding multiple neoplastic lesions that fitted the MEN- 1 syndrome spectrum, during the initial staging and subsequent follow-up of a breast tumour. In line with the growing evidence that links MEN-1 syndrome to breast cancer tumorigenesis, this case report highlights the following question: should we start screening this subset of patients earlier for breast cancer? [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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