Synthesis and Crystal Structure of Chalcone Derivatives and Their Effect on α-Glucosidase.

Autor: Lin, Ping, Yin, Zhong-Ping, Wang, Meng, Liu, Jia, Yuan, En, Peng, Da-Yong, Nie, Xu-Liang, Shang-Guan, Xin-Chen
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Zdroj: Journal of Chemical Crystallography; Sep2020, Vol. 50 Issue 3, p249-254, 6p
Abstrakt: Five chalcone derivatives (E)-1-(2-(2-bromoethoxy)phenyl)-3-phenylprop-2-en-1-one(1), (E)-1-(2-(3-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(2),(E)-1-(2-(4-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(3),(E)-1-(2-(5-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(4),(E)-1-(2-(6-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(5) were synthesized and characterized by 1H NMR, HRMS. The crystalline structures of compounds 4 and 5 were further characterized by X-ray crystal diffraction. Among the five compounds, 1 and 2 showed inhibitory activity on α-glucosidase, but 4 and 5 increased the activity of α-glucosidase. Five chalcone derivatives were synthesized and characterized by 1H MNR and HRMS. The crystalline structures of two compounds were further characterized by X-ray crystal diffraction. Two of the compounds have the ability to inhibit α-glucosidase, and two different compounds have the ability to promote α-glucosidase. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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