Sex steroid action in adolescence: too much, too little; too early, too late.

Autor: Hansen, A. B., Wøjdemann, D., Renault, C. H., Pedersen, A. T., Main, K. M., Raket, L. L., Jensen, R. B., Juul, A.
Předmět:
Zdroj: European Journal of Endocrinology; 2021, Vol. 184 Issue 1, pR17-R28, 12p
Abstrakt: This review aims to cover the subject of sex steroid action in adolescence. It will include situations with too little sex steroid action, as seen in for example, Turners syndrome and an drogen insensitivity issues, too much sex steroid action as seen in adolescent PCOS, CAH and gynecomastia, too la te sex steroid action as seen in constitutional delay of growth and puberty and too early sex steroid action as seen in precocious puberty. This review will cover the etiology, the signs and symptoms which the clinician should be attentive to, important differential diagnoses to know and be able to distinguish, long-term health and social consequences of these hormonal disorders and the course of action with regards to medical treatment in the pediatric endocrinolog ical department and for the general practitioner. This review also covers situations with exogenous sex steroid applic ation for therapeutic purposes in the adolescent and young adult. This includes gender-affirming therapy in the transg ender child and hormone treatment of tall statured children. It gives some background information of the cause of treatment, the patient's motivation for medicating (or self-medicating), long-term consequences of exogenous sex steroid treatment and clinical outcome of this treatment. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index