| Autor: |
Laplana, Marina, Bravo, Maria Jose, Fernández-Fuertes, Marta, Ruiz-Garcia, Celia, Alarcón-Martin, Emilio, Colmenero, Juan de Dios, Caruz, Antonio, Fibla, Joan, Real, Luis Miguel, Royo, Jose Luis, Laplana, M, Bravo, M J, Fernández-Fuertes, M, Ruiz-Garcia, C, Alarcón-Martin, E, Colmenero, J D, Caruz, A, Fibla, J, Real, L M, Royo, J L |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 12/15/2020, Vol. 222 Issue 12, p2007-2011, 5p |
| Abstrakt: |
Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its role in human immunodeficiency virus type 1 (HIV-1) infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+ < 200 cells/μL outcome for deletion allele carriers (Cox regression analysis: hazard ratio, 2.4 [95% confidence interval, 1.4-4]; P = .001). When naive patients with CD4+ < 200 cells/μL started antiretroviral treatment, rs111200466-deletion carriers showed a trend toward a slower, recovery rate (time required to reach CD4+ > 350 cells/μL; Cox P = .36). Our data suggest rs111200466 as a prognosis factor for HIV-1 disease progression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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