| Autor: |
Bing Liu, Wan-Ling Ma, Guang-Wen Zhang, Zhen Sun, Meng-Qi Wei, Wei-Huan Hou, Bing-Xin Hou, Li-Chun Wei, Yi Huan |
| Předmět: |
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| Zdroj: |
BMC Medical Imaging; 8/14/2020, Vol. 20, p1-9, 9p |
| Abstrakt: |
Background: To testify whether multi-b-values diffusion-weighted imaging (DWI) can be used to ultra-early predict treatment response of concurrent chemoradiotherapy (CCRT) in cervical cancer patients and to assess the predictive ability of concerning parameters. Methods: Fifty-three patients with biopsy proved cervical cancer were retrospectively recruited in this study. All patients underwent pelvic multi-b-values DWI before and at the 3rd day during treatment. The apparent diffusion coefficient (ADC), true diffusion coefficient (Dslow), perfusion-related pseudo-diffusion coefficient (Dfast), perfusion fraction (f), distributed diffusion coefficient (DDC) and intravoxel diffusion heterogeneity index(a) were generated by mono-exponential, bi-exponential and stretched exponential models. Treatment response was assessed based on Response Evaluation Criteria in Solid Tumors (RECIST v1.1) at 1 month after the completion of whole CCRT. Parameters were compared using independent t test or Mann-Whitney U test as appropriate. Receiver operating characteristic (ROC) curves was used for statistical evaluations. Results: ADC-T0 (p = 0.02), Dslow-T0 (p < 0.01), DDC-T0 (p = 0.03), ADC-T1 (p < 0.01), Dslow-T1 (p < 0.01), ADC (p = 0.04) and a (p < 0.01) were significant lower in non-CR group patients. ROC analyses showed that ADC-T1 and a exhibited high prediction value, with area under the curves of 0.880 and 0.869, respectively. Conclusions: Multi-b-values DWI can be used as a noninvasive technique to assess and predict treatment response in cervical cancer patients at the 3rd day of CCRT. ADC-T1 and a can be used to differentiate good responders from poor responders. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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