| Autor: |
Abdelhadi, Maha, Khalifa, Ghada, Nasr, Soha Atef, Rasheed, Enas Abdel, Ganem, Mona M. F., Elgendy, Aliaa, EL Mola, Soad Saeed Ahmed |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Apr2020, Vol. 11 Issue 4, p992-998, 7p |
| Abstrakt: |
Dialysis-related amyloidosis (DRA) is one of important complications occurring in hemodialysis patients and often presentsing as carpal tunnel syndrome (CTS), chronic arthropathy,subchondral cysts and pathological fracture tendency.In hemodialysis patients, there is increasing levels of beta-2-microglobulin (β-2m) in the plasma which is an important factor in DRA pathogenesis. DRA commonly presents with CTS which is diagnosed clinically and verified by nerve conduction examination.Also(DRA) is main inducer of arthropathies in chronic HD patients due to β-2M accumulation forming amyloid fibrils which are deposited mainly on articular structures predominantly on articular cartilage in the early stage of DRA. Cartilage biomarkers whether collagenous or non -collagenous are corresponding to cartilage destruction, degradation and turnover so their assessment is valuable in osteoarticular complications in HD patients. The aim of this study is to access cartilage biomarkers, β-2m and PTX3 level changes in patients with DRA, their correlation to each other and to the clinical condition with evaluation of their value in diagnosis of DRA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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