Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor.

Autor: Decorbie, N., Tijunelyte, I., Gam-Derouich, S., Solard, J., Lamouri, A., Decorse, P., Felidj, N., Gauchotte-Lindsay, C., Rinnert, E., Mangeney, C., Lidgi-Guigui, N.
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Zdroj: Plasmonics; Oct2020, Vol. 15 Issue 5, p1533-1539, 7p
Abstrakt: In this article, we propose a new strategy to build a sensor for easy handling and rapid analysis on-site. Our sensor is based on the combination of surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs). SERS provides a strong sensitivity for the detection of trace molecules while MIPs offer a highly selective and specific recognition platform. The research presented here focuses on the detection of the interaction between a robust ultra-thin layer of MIPs and of paracetamol, the targeted molecule. This drug is an environmental emerging pollutant, i.e., a molecule whose presence and significance have not yet been elucidated, which gives rise to health and environmental concerns. The results are a combined analysis of the SERS spectra and a multivariate analysis. The former provides a clear demonstration of the evolution of the MIP-nanostructure interaction when the concentration of paracetamol increases. The statistical analysis produces the proof of the selectivity of the sensor. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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