| Autor: |
Al-wazni, Wafaa sadeq |
| Předmět: |
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| Zdroj: |
Magazine of Al-Kufa University for Biology; 2018, Vol. 10 Issue 3, p147-159, 13p |
| Abstrakt: |
Current study was designed in order to examine the immunological effect of biosurfactant material extracted from Serratia marcescens bacteria that showed a high ability to produce these materials. When studying the protective effect of biosurfactant extract against infective dose (LD50) of Salmonella typhi (as an indicator of the effectiveness of cellular immunity) and Staphylococcus aureus ) as an indicator of the effectiveness of humoral immune response) in normal and dexamethasone treated mice, the results showed high survival rate for mice treated with extract before 24 hr of infection with an LD50 of S.aureus and S.typhi and the survival rate of injected mice increased with increasing concentration of extract in compare with control group. In addition, this extract was examined for its mitogenic effects in the lymphocyte transformation test compared with phytohemagglutinin (PHA). The statistical analysis showed that there was no significant difference between the percentage recorded when using PHA(80.6%) and both 80 mg/ml (85.1%) and 40mg/ml (71.9) of biosurfactant in compare to negative control and low concentration of biosurfactant. The effect of extract on migration of polymorphonucler cell was examined and the result showed significant decrease in diameter of migration area especially at 80mg/ml concentration (11.5mm) in compare with negative control. It can be concluded that biosurfactant can act to stimulate immune system. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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