| Autor: |
Zainab, Saadia, Khan, Umar Ali, Lodhi, Ghulam Mustafa, Asad, Munazza |
| Předmět: |
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| Zdroj: |
Pakistan Armed Forces Medical Journal; Jun2020, Vol. 70 Issue 3, p776-780, 5p |
| Abstrakt: |
Objective: To determine the chronic stress induced decline in plasma Neuropeptide Y (NPY) level and protective effects of Alpha Tocopherol (AT) on maintenance of Neuropeptide Y level. Study Design: Quasi-experimental study. Place and Duration of Study: The study settings were Al-Nafees Medical College and animal center of National Institute of Health Islamabad (NIH). Duration of research was one year from May 2015 to May 2016. Methodology: After taking approval of institutional review board 45 male Sprague Dawley rats with inclusion criteria were chosen and allocated to three groups comprised of n=15. Group I was control, group II restraint stress and group III (restraint stress with supplementation of alpha-tocopherol). After 28 days of restraining stress induction plasma Neuropeptide Y level was determined by sandwich Enzyme Linked Immunosorbent Assay (ELISA). Results: There was a statistically significant decline (p<0.05) in plasma Neuropeptide Y levels in restraint group as compared to control group and with alpha-tocopherol supplementation group. Conclusion: Chronic restraint stress induction led to decline in Neuropeptide Y levels and alpha-tocopherol prevented fall in Neuropeptide Y levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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