| Autor: |
López-Merino, Ahidé, Contreras-Rodríguez, Araceli, Migranas-Ortiz, Roberto, Orrantia-Gradíin, Rubén, Hernández-Oliva, Gerardo M., Y Gutiérrez-Rubio, Arturo Torres, Cardeñosa, Oscar |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Infectious Diseases; Sep2004, Vol. 36 Issue 9, p636-638, 3p |
| Abstrakt: |
Brucellosis is a disease of domestic and wild animals that is transmitted to humans and exists worldwide. We assessed the in vitro activity of moxifloxacin, ciprofloxacin, tetracycline, doxicycline, rifampin, streptomycin and trimethoprim-sulfamethoxazole (TMP/SMX) against 97 Brucella strains isolated from clinical samples, animals and dairy products in Mexico. Fluoroquinolones showed an antibacterial activity similar to that of tetracyclines (MIC 90 0.5). Other drugs commonly used against brucellosis were less active, such as rifampin (MIC 90 2.0 μg/ml) and streptomycin (MIC 90 4.0 μg/ml). TMP/SMX showed the poorest activity (MIC 90 8.0 μg/ml). Fluoroquinolones, either first-generation or the newer 8-methoxi derivatives, might be useful in the therapy of brucellosis, which remains to be assessed in clinical trials. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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