The Mechanism of the Stimforte Effect on the Activation of Target Cell Defense against Viral Infection.

Autor: Mal'dov, D. G., Deryabin, P. G., Grigoryan, S. S., Mishin, D. V., Andronova, V. L., Isaeva, E. I., Galegov, G. A., Ilichev, A. V.
Zdroj: Doklady Biological Sciences; Mar2020, Vol. 491 Issue 1, p50-53, 4p
Abstrakt: Stimforte in a wide range of concentrations (15–225 µg/mL) totally inhibits the cytopathic activity of hepatitis C virus (HCV) in the Vero-V cell culture. Interferons (IFN) play the most important role in the suppression of infection when the drug is introduced into the culture before the infection. When Stimforte is introduced after the infection, the mechanism of action seems to be different. The activators of IFN production are mainly (or exclusively) the ligands of receptor complexes TLR-4 and NOD-2 contained in the drug. The action of these substances is probably synergistic, similar to the action of LPS and MDP in Vero-V cells. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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