| Autor: |
Motta, Raphael J. G., Almeida, Luciana Yamamoto, Villafuerte, Kelly R. V., Ribeiro-Silva, Alfredo, León, Jorge E., Tirapelli, Camila |
| Předmět: |
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| Zdroj: |
Journal of Periodontal Research; Jun2020, Vol. 55 Issue 3, p374-380, 7p, 1 Black and White Photograph, 2 Charts |
| Abstrakt: |
Background and Objective: Some studies suggest that regulatory T cells (Tregs) have suppressive effects on inflammatory osteolysis. The aim of this study was to evaluate Treg immunomarkers in periodontitis‐affected tissues from patients with periodontitis and clinically healthy gingiva (control). Material and Methods: The presence and distribution of positive cells for CD4, CD25 and FOXP3 (Treg immunomarkers) in periodontitis‐affected tissues (epithelium and lamina propria) of 30 patients (ten per group) with a diagnosis of stage IV, grade C periodontitis (IV‐C), stage III, grade B periodontitis (III‐B) and the control were evaluated. A two‐way ANOVA followed by Fisher's LSD test was used to demonstrate differences between the groups and immunomarkers; Student's t test was used to demonstrate differences between the epithelium and the lamina propria. Results: Both IV‐C and III‐B periodontitis presented a significantly high proportion of immune‐stained cells for all immunomarkers when compared to the control group. Notably, CD25+ and FOXP3+ cells were detected in a significantly higher number in III‐B than IV‐C periodontitis (P <.05). Conclusion: Our results suggest the participation of Tregs on the osteoimmunological mechanisms in IV‐C and III‐B periodontitis patients, notably contributing to strategies for alveolar bone regeneration in clinical treatment decisions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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