| Autor: |
Copping, K. J., Hernandez-Medrano, J., Hoare, A., Hummitzsch, K., McMillen, I. C., Morrison, J. L., Rodgers, R. J., Perry, V. E. A. |
| Předmět: |
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| Zdroj: |
Reproduction, Fertility & Development; 2020, Vol. 32 Issue 5, p495-507, 13p |
| Abstrakt: |
Few studies have investigated the effects of nutrition during the periconception and early gestation periods on fetal and placental development in cattle. In this study, nulliparous yearling heifers (n = 360) were individually fed a diet high or low in protein (HPeri and LPeri) beginning 60 days before conception. From 24 to 98 days after conception, half of each treatment group was changed to the alternative high- or low-protein diet (HPost and LPost) yielding four groups in a 2 × 2 factorial design. A subset of heifers (n = 46) was necropsied at 98 days after conception and fetoplacental development assessed. Placentome number and volume decreased in response to LPeri and LPost diets respectively. Absolute lung, pancreas, septum and ventricle weights decreased in LPost versus HPost fetuses, whereas the post-conception diet altered absolute and relative liver and brain weights depending on sex. Similarly, changes in fetal hepatic gene expression of factors regulating growth, glucose output and lipid metabolism were induced by protein restriction in a sex-specific manner. At term, neonatal calf and placental measures were not different. Protein restriction of heifers during the periconception and early gestation periods alters fetoplacental development and hepatic gene expression. These changes may contribute to functional consequences for progeny, but this may not be apparent from gross morphometry at birth. This study is the first to show that moderate protein restriction in yearling heifers during the periconception and early-gestation periods is concomitant with sex-specific asymmetric restriction of fetoplacental development. Sex-specific programming effects were observed on genes regulating growth, hepatic glucose output and lipid metabolism in the 98 dpc fetus. These findings provide insights into the underlying molecular pathways that promote susceptibility to increased postnatal fat deposition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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