Electron Microscopy and X-ray Diffraction Studies further Confirm the Efficacy of PTI-00703® (Cat's Claw Derivative) as a Potential Inhibitor of Alzheimer's β-Amyloid Protein Fibrillogenesis.

Autor:	Castillo, Gerardo M., Kirschner, Daniel A., Yee, Ann G., Snow, Alan D.
Předmět:	ALZHEIMER'S disease ELECTRON microscopy X-ray diffraction AMYLOID GLYCOPROTEINS PEPTIDES
Zdroj:	Alzheimer's Disease: Advances in Etiology, Pathogenesis & Therapeutics; 2001 1st Edition, p449-460, 12p
Abstrakt:	Alzheimer's disease is characterized by the accumulation in the brain parenchyma of insoluble fibrillar deposits, 'plaques', that contain the β-amyloid protein. Studies suggest that providing agents or compounds that are capable of inhibiting this assist patients with Alzheimer's disease. In our search for possible natural inhibitors of β-amyloid fibrillogenesis, we have discovered PTI-00703®, which is a proprietary aqueous extract derived from the bark of the rain forest woody vine known as Ucaria tomentosa or cat's claw. The purpose of the present study was further to determine the in vivo effects of the plant derivative PTI-00703® on inhibition of β-amyloid fibril formation. [ABSTRACT FROM PUBLISHER]
Databáze:	Complementary Index
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