Systematic review of neurotrophic tropomyosin-related kinase inhibition as a tumor-agnostic management strategy.
| Autor: | Chu, Paula, Batson, Sarah, Hodgson, Matthew, Mitchell, Catherine R, Steenrod, Anna |
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| Předmět: |
PROTEIN metabolism
THERAPEUTIC use of antineoplastic agents MUSCLE protein metabolism PROTEINS RESEARCH MUSCLE proteins META-analysis PROTEIN kinase inhibitors RESEARCH methodology SYSTEMATIC reviews ANTINEOPLASTIC agents EVALUATION research MEDICAL cooperation TREATMENT effectiveness COMPARATIVE studies PROTEIN-tyrosine kinases QUALITY of life TUMORS DISEASE management CHEMICAL inhibitors |
| Zdroj: | Future Oncology; Feb2020, Vol. 16 Issue 4, p61-74, 14p |
| Abstrakt: | Aim: To conduct a systematic review and meta-analysis feasibility of clinical, quality of life and economic evidence for neurotrophic tropomyosin-related receptor tyrosine kinases (NTRK) inhibitors in patients with NTRK gene fusion-positive tumors. Materials & methods: Databases were searched for studies on NTRK inhibitors in adult and pediatric patients. Results: 27 publications reported clinical data for seven interventions. Efficacy/safety data were available for two interventions only. Four trials each reported data for larotrectinib and entrectinib with pooled analyses reporting objective response rates of 75% (95% CI: 61-85) and 57.4% (43.2-70.8), respectively. No publications reported economic or quality of life evidence. Conclusion: Preliminary data demonstrate that NTRK inhibitors are well tolerated and show impressive clinical benefit; corroboration of existing studies and real-world data are required. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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