| Autor: |
Belfiore, Marco Belfiore, Pugnale, Paolo, Saudan, Zarifja, Puoti, Alessandro |
| Předmět: |
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| Zdroj: |
Development (09501991); Jun2004, Vol. 131 Issue 12, p2935-2945, 11p, 3 Color Photographs, 1 Black and White Photograph, 5 Diagrams, 1 Chart |
| Abstrakt: |
The switch from spermatogenesis to oogenesis in the Caenorhabditis elegans hermaphrodite requires mog-6, which post-transcriptionally represses the fern-3 RNA. In this study, we show that mog-6 codes for a divergent nuclear cyclophilin, in that a conserved domain is not required for its function in the sperm-oocyte switch. MOG6 binds to the nuclear zinc finger protein MEP-1 through two separate domains that are essential for the role of MOG-6 in the sperm-oocyte switch. We propose that MOG-6 has a function distinct from that of prevailing cyclophilins and that its binding to MEP-1 is essential for germline sex determination. Finally, we found that gld-3 mog-6 mutants develop germline tumors, suggesting that mog-6 might function in the decision between mitosis and meiosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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