| Autor: |
Smith, Kathleen J., Skelton, Henry C., Yeager, Josef, Tuur, Sylvana, Angritt, Peter, Wagner, Kenneth F. |
| Předmět: |
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| Zdroj: |
International Journal of Dermatology; Oct1997, Vol. 36 Issue 10, p745-753, 9p |
| Abstrakt: |
Background There have been scattered reports of HIV +patients with increased reactions to tight as well as anecdotal reports of HIV+ patients with increased morbidity secondary to radiation therapy. Method As a part of a miIitary study of HIV patients, we followed 987 patients for cutaneous disease for 4 years. All patients were questioned on a periodic basis about increased sensitivity to light. These patients received a physical examination at each protocol visit, and they were given the opportunity to receive all their dermatologic care within the HIV clinic Fourteen of the patients with photo induced eruptions were evaluated clinically at the time of the eruption, and 11 of these were biopsied. Results Thirty-three of the patients reported photo-induced reactions unrelated to oral medications Although sensitivity to light often began in the early stages of HIV disease, reactions became more severe and more chronic with disease progression Histologic features varied from few to numerous apoptotic/necrotic keratinocytes within the mid to upper levels of the epidermis associated with a perivascular inflammatory infiltrate, to apoptotic/necrotic keratinocytes throughout an acanthotic epidermis with a lichenoid/ interface infiltrate. Conclusions Although the pathogenesis of these light reactions is not known, these reactions may be related to depletion of endogenous scavengers which results in increased. oxidative stress and is modulated by the pattern of immune dysregulation and metabolic dysregulation induced by HIV disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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