| Autor: |
Arçay, Ayça, Aydın, Funda, Kıprak, Zeynep Gül, Kutlu, Ömer, Güngör, Ahmet Fırat |
| Předmět: |
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| Zdroj: |
Nuclear Medicine Seminars; 2019 Supplement 1, Vol. 5, p49-50, 2p |
| Abstrakt: |
Aim: PSMA is spesific for prostate cancer cells but uptake on PSMA PET/CT in uncommon locations for prostate cancer metastasis must be considered for second malignancies. We report a case of abdominal mesenchymal tumor showing heterogenous PSMA uptake in the left upper abdomen. Case: A 50-year-old man with recently diagnosed prostate adenocarcinoma (Gleason score 3+3; initial PSA, 16.6 ug/L) was referred for Ga-68 PSMA PET/CT to assess for metastatic disease. Ga-68 PSMA PET/CT revealed mildy increased focal tracer uptake (SUVmax: 6.1) in the left part of prostate gland, diffusion MR scan showed no diffusion restriction or contrast enhancement in this region. No prominent pathological metastatic focus was detected. The scan, however, revealed a lesion of 120x92 mm diameters in the left upper abdomen. It had heterogenously increased PSMA uptake (SUVmax: 16.9) and also had cold areas at the posterior region. Histological examination of tissue obtained by core biopsy revealed mesenchymal tumor with spindle cells; no prominent mitosis, necrosis or atypia was seen. The lesion was interpreted as gastrointestinal/extragastrointestinal stromal tumor by pathologists. Conclusion: Ga-68 PSMA uptake has been described in a large number of non-prostate malignancies-hepatocellular carcinoma, papillary thyroid carcinoma, lung cancer, follicular lymphoma and pancreatic neuroendocrine tumor. PSMA expression is markedly increased in the prostate cancer cells compared to benign tissue, PSMA is also expressed in the endothelial cells of tumor-associated neovasculature. The possible explanation of PSMA expression in nonprostate malignancies is that. Different PSMA uptake patterns of GIST have been reported in several cases like peripheral uptake and central necrosis, rather homogenous intense uptake, focal uptake, moderate heterogenous uptake. Therefore, GIST PSMA uptake pattern is not uniform. PSMA uptake in unusal sites for prostate cancer metastasis must be kept in mind for second malignancies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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