| Autor: |
Nguyen, Nhi Y. T., Dang, Phu H., Nguyen, Van T. T., Dang, Phuc H., Tran, Quan L. |
| Předmět: |
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| Zdroj: |
Natural Product Research; Jul2019, Vol. 33 Issue 13, p1903-1908, 6p |
| Abstrakt: |
From an EtOAc-soluble fraction of the leaves of Azadirachta indica, one new lactam 28-norlimonoid named nimbandiolactam-21 (1), together with 2 known limonoids (2 and 3) were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Nimbandiolactone-23 (2) showed the most potent α-glucosidase inhibitory activity, with an IC50 value of 38.7 μM. Compound 1 represents the first naturally occurring example of a 28-norlimonoid having the lactam moiety. The plausible biosynthetic pathway for the formation of lactam moiety in 1 was proposed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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