New Amides and Phenylpropanoid Glucosides from the Fruits of Piper retrofractum.

Autor:	Tang, Rong, Zhang, Ya-Qiong, Hu, Dong-Bao, Yang, Xue-Fei, Yang, Jun, San, Myint Myint, Oo, Thaung Naing, Kong, Yi, Wang, Yue-Hu
Předmět:	AMIDES GLUCOSIDES PHENYLPROPANOIDS PIPER (Genus) BLOOD platelet aggregation PLATELET aggregation inhibitors CHEMICAL structure
Zdroj:	Natural Products & Bioprospecting; Jun2019, Vol. 9 Issue 3, p231-241, 11p
Abstrakt:	Two new amides (E)-N-cinnamoyl-2-methoxypiperidine (1) and (R)-1-(2-oxopyrrolidin-3-yl)-5,6-dihydropyridin-2(1H)-one (2), four new amide glucosides, retrofractosides A–D (3–6), and two new phenylpropanoid glucosides, retrofractosides E (7) and F (8), together with 24 known compounds (9–32) were isolated from the fruits of Piper retrofractum. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. All of these isolates (1–32) were evaluated for inhibitory activity against mouse platelet aggregation induced by the peptide AYPGKF-NH2. (E)-N-(Tetrahydro-2H-pyran-2-yl)cinnamamide (9) showed a weak inhibitory effect, with an inhibition ratio of 52.0% at a concentration of 150 μM. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink