| Autor: |
Bouderlique, Thibault, Peña-Pérez, Lucia, Kharazi, Shabnam, Hils, Miriam, Li, Xiaoze, Krstic, Aleksandra, De Paepe, Ayla, Schachtrup, Christian, Gustafsson, Charlotte, Holmberg, Dan, Schachtrup, Kristina, Månsson, Robert |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; 3/18/2019, pN.PAG-N.PAG, 13p |
| Abstrakt: |
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Common lymphoid precursors (CLPs) and a near complete block in B-cell development. In the thymus, Early T-cell progenitors (ETPs) were reduced and T-cell development perturbed, resulting in reduced CD4 T- and increased γδ T-cell numbers. In contrast, hematopoietic stem cells (HSCs), erythro-myeloid progenitors, and innate immune cells were unaffected showing that E2-2 and HEB are dispensable for the ancestral hematopoietic lineages. Taken together, this E-protein dependence suggests that the appearance of the full Gnathostomata E-protein repertoire was critical to reinforce the gene regulatory circuits that drove the emergence and expansion of the lineages constituting humoral immunity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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