| Autor: |
Ma, Yue, Zhu, Yongping, Zhang, Dong, Meng, Yuqing, Tang, Tian, Wang, Kun, Ma, Ji, Wang, Jigang, Sun, Peng |
| Předmět: |
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| Zdroj: |
Green Chemistry; 2/7/2019, Vol. 21 Issue 3, p478-482, 5p |
| Abstrakt: |
An environmentally benign decarboxylative cyclization in water has been developed to synthesize 4-quinolones from readily available isatoic anhydrides and 1,3-dicarbonyl compounds. Isatins are also compatible for the reaction to generate 4-quinolones in the presence of TBHP in DMSO. This protocol provides excellent yields under mild conditions for a broad scope of 4-quinolones, and has good functional group tolerance. Only un-harmful carbon dioxide and water are released in this procedure. Moreover, the newly synthesized products have also been selected for anti-malarial examination against the chloroquine drug-sensitive Plasmodium falciparum 3D7 strain. 3u is found to display excellent anti-malarial activity with an IC50 value of 33 nM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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