| Autor: |
NURUL HUSNA MD JANI, DAUD, DZULSUHAIMI, SHARKAWI, NURSIRHAN, HASHIM, HARITA, NUR HILWANI ISMAIL, SALLEH, AZANI, HASHIM, NOORAAIN |
| Předmět: |
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| Zdroj: |
Malaysian Applied Biology; Nov2018, Vol. 47 Issue 5, p181-187, 7p |
| Abstrakt: |
Obesity is a worldwide health problem that may impose infertility risks in males. This study was designed to determine the effect of Zingiber zerumbet rhizome ethanol extract (ZZREE) on testosterone levels and testes histology in high fat dietinduced obese rats. Rats were fed with high fat diet (HFD) containing 50% rat chow pellet, 20% pure ghee, 20% full cream milk powder, 6% corn starch and 4% corn oil, ad libitum daily to induce obesity. Twenty obese rats were randomly divided into 4 groups (n=5). A group of obese rats (n=5) was treated with 1% body weight (bwt) of saline and served as a negative control while another 3 groups (n=5) of obese rats were treated orally with 200, 300, 400 mg/kg bwt of ZZREE, respectively. In addition, a group of non-obese rats (n=5) was treated with 1% bwt of saline and served as normal control. At the end of experiment, blood and testes tissues were collected for testosterone assay and histological studies. The testosterone levels of HFD-induced obese rats treated with ZZREE at all concentrations significantly increased (p<0.05) compared to the negative control. ZZREE also significantly increased (p<0.05) the Johnsen's scores, decreased the diameter of lumens (p<0.05) and increased the width of the spermatid-sperm layers (p<0.05) in HFD-induced obese rats, indicating improved spermatogenesis. Therefore, it can be concluded that ZZREE showed positive effects in improving testosterone secretion and spermatogenesis in HFD-induced obese rats. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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