Concanavalin-A displays leishmanicidal activity by inducing ROS production in human peripheral blood mononuclear cells.

Autor: Thomazelli, Ana Paula Fortes dos Santos, Tomiotto-Pellissier, Fernanda, Miranda-Sapla, Milena Menegazzo, da Silva, Suelen Santos, Alvarenga, Daniele Sapede, Panis, Carolina, Cataneo, Allan Henrique Depieri, Bordignon, Juliano, Silveira, Guilherme Ferreira, Yamauchi, Lucy Megumi, de Sá, Jussevania Pereira Santos Rubro, Felipe, Ionice, Pavanelli, Wander Rogério, Conchon-Costa, Ivete
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Zdroj: Immunopharmacology & Immunotoxicology; Oct2018, Vol. 40 Issue 5, p387-392, 6p
Abstrakt: The context of the article: Leishmania amazonensis has a wide geographical distribution throughout South American countries and can cause self-healing to severe cases as mucocutaneous or visceral forms. Leishmaniasis presents a balance of inflammatory and anti-inflammatory cytokines which is responsible for promoting the activation of phagocytes, essential to control the infection and lead to tissue repair/resolution of the disease, respectively. Results and discussion: Our model revealed that the treatment with Con-A was capable to stimulate human PBMC cells by increasing the phagocytic capacity and promoting parasite elimination. The pretreatment with Con-A promoted inflammatory (IFN-γ, TNF-α, IL-2 and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokines production, increased the reactive oxygen species (ROS) sinthesys as well as the expression and presence of iNOS enzyme, but not nitric oxide production. Conclusion: Based on the data obtained, it was possible to infer that Con-A induces the ROS production, responsible for eliminating parasites in addition to regulatory cytokines synthesis which are important for disease resolution. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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