Treatment of the Mayer-Rokitansky-Küster-Hauser syndrome with autologous in vitro cultured vaginal tissue: descriptive study of long-term results and patient outcomes.

Autor:	Sabatucci, I, Palaia, I, Marchese, C, Muzii, L, Morte, C Della, Giorgini, M, Musella, A, Ceccarelli, S, Vescarelli, E, Panici, PB, Panici, P B
Předmět:	MAYER-Rokitansky-Kuster-Hauser syndrome VAGINOPLASTY AUTOTRANSPLANTATION QUALITY of life HEALTH outcome assessment VAGINAL surgery AUTOGRAFTS HUMAN abnormalities GYNECOLOGIC surgery INTERSEXUALITY HUMAN sexuality PLASTIC surgery EMBRYOS TREATMENT effectiveness SURGERY
Zdroj:	BJOG: An International Journal of Obstetrics & Gynaecology; Jan2019, Vol. 126 Issue 1, p123-127, 5p, 3 Charts
Abstrakt:	Objective: Evaluating sexual function and quality of life (QoL) in patients treated with a modified Abbé-McIndoe technique using in vitro cultured autologous vaginal mucosa.Design: Descriptive study.Setting: Policlinico Umberto I, Sapienza University of Rome.Population: From 2006 to 2016, 39 women affected by Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) underwent vaginoplasty at our centre using a modified Abbé-McIndoe technique with in vitro cultured autologous vaginal tissue.Methods: For each patient, vaginal tissue was obtained by full-thickness biopsy of the vaginal vestibule. Following enzymatic dissociation, cells were cultured for 2-3 weeks before the transplant.Main Outcome Measures: Each patient completed two validated questionnaires to quantify sexual function and QoL: the Female Sexual Function Index (FSFI), administered at 12, 36, and 60 months, and the Psychological General Well Being Index (PGWBI) administered at 0, 6, and 36 months after surgery.Results: Twelve months after surgery, 29 patients were engaging in regular sexual activity. The FSFI test results showed a satisfactory sexual function compared to the general population, with median values of 25.85 (range 4.6-30.5) at 12 months, 27.2 (range 4.4-33.6) at 36 months, and 29.6 (range 23.9-33.6) at 60 months. The PGWBI questionnaire showed a median score of 420.5 (range 108-540) before surgery, and 459 (range 252-533) at the 60-month follow-up.Conclusions: Vaginoplasty performed with the use of autologous vaginal tissue, besides ensuring a long-term satisfying sex life, helps in achieving an improvement in QoL that is maintained over time.Tweetable Abstract: Vaginoplasty using in vitro vaginal tissue ensures a satisfactory sexual function and improves quality of life. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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