| Autor: |
Boussaïd, Ghilas, Prigent, Hélène, Laforet, Pascal, Raphaël, Jean-Claude, Annane, Djillali, Orlikowski, David, Lofaso, Frédéric |
| Předmět: |
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| Zdroj: |
Thorax; Nov2018, Vol. 73 Issue 11, p1075-1078, 4p, 1 Illustration, 1 Chart |
| Abstrakt: |
Few studies have assessed the impact of home ventilation in patients with myotonic dystrophy type 1 (DM1) and no specific recommendations are available. We assessed the survival associated with category of home ventilation adherence of patients with DM1 followed up at a home ventilation unit using a Cox proportional hazards model. 218 patients were included; those who refused or delayed their acceptance of non-invasive ventilation were at higher risk for severe events (invasive ventilation or death) (P=0.03). Risk of death was associated with orthopnoea (HR 2.37; 95% CI 1.17 to 4.80; P<0.02) and adherence category (100 to 90% vs >75%: HR 3.26; 95% CI 1.32 to 8.04; P<0.03). Failure to use home ventilation as prescribed may be associated with increased mortality in patients with DM1. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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