Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India.

Autor: Munusamy Ponnan, Sivasankaran, Swaminathan, Soumya, Tiruvengadam, Kannan, K. K., Vidyavijayan, Cheedarla, Narayana, Nesakumar, Manohar, Kathirvel, Sujitha, Goyal, Rajat, Singla, Nikhil, Mukherjee, Joyeeta, Bergin, Philip, T. Kopycinski, Jakub, Gilmour, Jill, Prasad Tripathy, Srikanth, Elizabeth, Luke Hanna
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Zdroj: PLoS ONE; 8/29/2018, Vol. 13 Issue 8, p1-16, 16p
Abstrakt: A Phase I HIV-1 vaccine trial sponsored by the International AIDS Vaccine Initiative (IAVI) was conducted in India in 2009 to test a subtype C prophylactic vaccine in a prime-boost regimen comprising of a DNA prime (ADVAX) and MVA (TBC-M4) boost. The trial demonstrated that the regimen was safe and well tolerated and resulted in enhancement of HIV-specific immune responses. Preliminary observations on vaccine-induced immune responses were limited to analysis of neutralizing antibodies and IFN-γ ELISPOT response. The present study involves a more detailed analysis of the nature of the vaccine-induced humoral immune response using specimens that were archived from the volunteers at the time of the trial. Interestingly, we found vaccine induced production of V1/V2 and V3 region-specific antibodies in a significant proportion of vaccinees. Variable region antibody levels correlated directly with the frequency of circulating T follicular helper cells (Tfh) and regulatory T cells (Treg). Our findings provide encouraging evidence to demonstrate the immunogenicity of the tested vaccine. Better insights into vaccine-induced immune responses can aid in informing future design of a successfulHIV-1 vaccine. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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