Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil.

Autor: Melo, Laura Gomes Nunes, Morales, Paulo Henrique, Drummond, Karla Rezende Guerra, Santos, Deborah Conte, Pizarro, Marcela Haas, Barros, Bianca Senger Vasconcelos, Mattos, Tessa Cerqueria Lemos, Pinheiro, André Araújo, Mallmann, Felipe, Leal, Franz Schubert Lopes, Malerbi, Fernando Korn, Gomes, Marilia Brito, Pinheiro, André Araújo
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Zdroj: BMC Public Health; 8/8/2018, Vol. 18 Issue 1, pN.PAG-N.PAG, 1p, 1 Diagram, 3 Charts
Abstrakt: Background: Diabetic retinopathy is the leading cause of blindness in economically active populations. The aims of this study were to estimate the prevalence and to identify risk factors for diabetic retinopathy in patients with type 1 diabetes in Brazil.Methods: This was a nationwide, cross-sectional study conducted between August 2010 and August 2014. The study included 1760 patients with type 1 diabetes. Patients underwent a standard questionnaire, clinical and laboratory analyses and were screened for diabetic retinopathy. To analyze the risk factors related to diabetic retinopathy, two models of logistic regression models were performed, one considering vision-threatening cases and the other with any diabetic retinopathy cases as dependent variables. The group with vision-threatening included patients with severe non-proliferative diabetic retinopathy, proliferative diabetic retinopathy and macular edema.Results: In total, 1644 patients (mean age, 30.1± 12.0 years; duration of diabetes, 15.3 ± 9.3 years; female, 55.8%) were studied. 35.7% presented diabetic retinopathy and 12% presented vision-threatening diabetic retinopathy. Three risk factors associated with diabetic retinopathy were in common to both groups: longer diabetes duration (OR 1.07; 95% CI, 1.05-1.09), higher levels of HbA1c (OR 1.24; CI, 1.17-1.32) and higher levels of serum uric acid (OR 1.22; CI, 1.13-1.31) (p < 0.001 for all comparisons).Conclusion: The higher rate of vision-threatening retinopathy found in our study highlights the need to improve access to eye care and screening programs for diabetic retinopathy in Brazil. In addition to traditional risk factors, we found an association between serum uric acid levels and diabetic retinopathy. Further studies are needed to address this association. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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